研究领域
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肿瘤和发育相关疾病的发生机制和干预手段,干细胞器官修复,表观遗传学,疾病动物模型。
近年来的研究工作围绕“组蛋白修饰与疾病”展开,在分子和细胞水平上构建了可靠的功能实验系统,重点研究了组蛋白修饰相关分子在多种疾病和发育中的作用,并构建了多个疾病动物模型,从分子和细胞水平,结合动物整体表型和临床样本分析,回答肿瘤和发育相关重大疾病的分子机理问题,为进一步研究这些疾病的分子机制与治疗提供了良好理论基础和可能的治疗靶点。
论文成果
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Di-Ras2 promotes renal cell carcinoma formation by activating the mitogen-activated protein kinase pathway in the absence of von Hippel-Lindau protein.Oncogene.2020
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Deficiency of Histone Methyltransferase SET Domain-Containing 2 in Liver Leads to Abnormal Lipid Metabolism and HCC.HEPATOLOGY.2021
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The histone methyltransferase Setd2 is indispensable for V(D)J recombination..Nat. Commun..2019
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Deficiency of Histone Methyltransferase SET Domain-Containing 2 in Liver Leads to Abnormal Lipid Metabolism and HCC.HEPATOLOGY.2021
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Multilevel Regulation of beta-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma.CANCER RESEARCH.2021
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Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.2021
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SETD2 is essential for terminal differentiation of erythroblasts during fetal erythropoiesis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2021
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SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. .Nat. Genet..2019