研究领域
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研究方向为基因组学、生物信息学和分子免疫学。采用生物统计、机器学习等生物信息学方法,以及3D基因组、蛋白质组等多组学和基因编辑等分子遗传学技术,研究基因表达调控规律和分子机制。主要研究成果发表于Cell、Molecular Cell、PNAS、Arthritis & Rheumatology和Biology等期刊,被Cell、Molecular Cell、Nature Reviews Rheumatology和Nature Reviews Molecular Cell Biology评论或推荐。
论文成果 MORE+
- · Chromatin jets define the properties of cohesin-driven in vivo loop extrusion.Molecular Cell.2022
- · Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery.NATURE COMMUNICATIONS.2022
- · 3D chromosomal landscape reveals miR-146a dysfunctional enhancer in lupus and establishes a CRISPR-mediated approach to inhibit the IFN pathway.Arthritis & Rheumatology.2023
- · Identification of Two Subsets of Subcompartment A1 Associated with High Transcriptional Activity and Frequent Loop Extrusion.Biology (Basel).2023
- · Chromatin jets define the properties of cohesin-driven in vivo loop extrusion.Molecular Cell.2022
- · CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function.Cell.2015
- · CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice.Proc. Natl. Acad. Sci. U.S.A..2012
- · Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin.PROTEIN & CELL.2019
- · Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection.GENOME BIOLOGY.2020
- · The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus.Nature Communications.2021
专利
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著作成果
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