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Lei Li
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Scientific Research
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Scientific Research
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Paper Publications：
Next-generation synthetic biology approaches for the accelerated discovery of microbial natural products.Engineering Microbiology.2022
Li L, Koirala B, Hernandez Y, MacIntyre LW, Russo R, Ternei MA, Brady SF*. Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens. Nature Microbiology 2022; 7:120-131
Li L, Wei KK, Liu XC, Wu YJ, Zheng GS, Chen SX, Jiang WH*, Lu YH*. aMSGE: advanced multiplex site-specific genome engineering with orthogonal modular recombinases in actinomycetes. Metabolic Engineering 2019; 52:153-167
Li L, Wei KK, Zheng GS, Liu XC, Chen SX, Jiang WH*, Lu YH*. CRISPR-Cpf1 assisted multiplex genome editing and transcriptional repression in Streptomyces. Applied and Environmental Microbiology 2018; 84:e00827-18
Li L, Zheng GS, Chen J, Ge M, Jiang WH*, Lu YH*. Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes. Metabolic Engineering 2017; 40:80-92
Li L, Zhao YW, Ruan LJ, Yang S, Ge M, Jiang WH*, Lu YH*. A stepwise increase in pristinamycin II biosynthesis by Streptomyces pristinaespiralis through combinatorial metabolic engineering. Metabolic Engineering 2015; 29:12-25
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微生物天然药物创新发现与高效制造
微生物源药物底盘发酵性能提升的机制与策略
新骨架微生物天然产物的生物合成与高效创制
抗真菌农药UK-2A产生菌会理链霉菌基因组编辑与分子育种研究
新型抗感染药物心磷脂结合抗生素（宏）基因组定向挖掘与活性评价
国家自然科学基金面上项目（2024-2027，主持）
中央高校优秀青年团队项目（2023-2026，课题主持）
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