研究领域
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研究方向为精确化学(Precision Chemistry)。精确化学就是探索理想的物质精确创造与转化的化学过程-HELLO Process。 包含从基本概念、基础理论和基元反应出发,主要针对芳烃、烷烃的惰性C-H键,经设计、试验、修正与验证,建立其新的高效、温和、环境友好的选择性活化功能化反应。研究所涉及的学科主要有金属有机、物理有机、催化、合成、计算化学等。
HELLO Process :
High yield 产物高收率;
Effecient pathway 高效率过程包含从选择最简单起始物开始,精密设计与选择最短路线和最少耗时的物质转化方式,如催化、一锅法及串联反应等,并选择使用相应的热、光、电、磁、机械等反应能量方式;
Low loading 精确控制全部物质最低量投入包含物质转化过程前、中、后的溶剂、底物、试剂及添加物等;
Low complexity 低复杂性的精准操作运行包含室温、常压和简单设备及高安全度等;
Only target product 核心是得到化学、区域和立体等唯一选择性的目标物质。
论文成果 MORE+
- · Equivalent Loading of Directed Arenes in Pd(II)-Catalyzed Oxidative Cross-Coupling of Aryl C–H Bonds at Room Temperature.J. Org. Chem..2021,86(3):2714–2733
- · 普通烷烃C―H键的活化官能化.物理化学学报.2019
- · Catalytic Bromination of Alkyl sp(3)C-H Bonds with KBr/Air under Visible Light.ORGANIC LETTERS.2018
- · Visible-Light-Driven Oxidation of N-Alkylamides to Imides Using Oxone/H2O and Catalytic KBr.SYNTHESIS.2018
- · Visible-Light-Driven Oxidative Mono- and Dibromination of Benzylic- sp3 C–H Bonds with Potassium Bromide/Oxone at Room Temperature.Synthesis .2018
- · Palladium-Catalyzed beta-Arylation of Amide via Primary sp(3)C-H Activation.ORGANOMETALLICS.2018
- · Palladium(II)-Catalyzed Oxidative Homo- and Cross-Coupling of Aryl ortho-sp(2) C-H Bonds of Anilides at Room Temperature.JOURNAL OF ORGANIC CHEMISTRY.2018
- · Visible Light-Induced Oxidative Chlorination of Alkyl sp(3) C-H Bonds with NaCl/Oxone at Room Temperature.ORGANIC LETTERS.2017
- · Transition-Metal- and Halogen-Free Oxidation of Benzylic sp3 C–H Bonds to Carbonyl Groups Using Potassium Persulfate.Synthesis.2017
- · Palladium-Catalyzed beta-Mesylation of Simple Amide via Primary sp(3) C-H Activation.ORGANIC LETTERS.2017