研究领域
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细胞自噬、细胞器、脂代谢。
利用现代分子生物学、细胞生物学方法，寻找作用于自噬体形成过程的新基因，进一步揭示自噬体形成的分子机理，理清上游信号转导网络对细胞自噬的调节作用，研究细胞自噬在疾病发生过程中的作用，探索通过干预细胞自噬减缓或治愈疾病的可行性。
论文成果 MORE+
- · 通过融合不同信号序列优化人源GPCR-beta2AR在酵母交配通路中的信号输出.Genomics and Applied Biology.2022
- · Visualizing Yeast Organelles with Fluorescent Protein Markers.JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.2022
- · A Validated Set of Ascorbate Peroxidase-Based Organelle Markers for Electron Microscopy of Saccharomyces cerevisiae.MSPHERE.2022
- · Vps21 Directs the PI3K-PI(3)P-Atg21-Atg16 Module to Phagophores via Vps8 for Autophagy.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022
- · Excess diacylglycerol at the endoplasmic reticulum disrupts endomembrane homeostasis and autophagy.BMC Biology.2020
- · Yeast lipid extraction and analysis by hptlc.Bio-protocol.2021
- · Assays for autophagy iii: Observing dynamic protein trafficking.Methods in Molecular Biology.2021
- · Membrane recruitment of Atg8 by Hfl1 facilitates turnover of vacuolar membrane proteins in yeast cells approaching stationary phase.BMC BIOLOGY.2021
- · Automated yeast cells segmentation and counting using a parallel U-Net based two-stage framework.OSA Continuum.2020
- · A Validated Set of Fluorescent-Protein-Based Markers for Major Organelles in Yeast (Saccharomyces cerevisiae).Mbio.2019
专利
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科研项目 MORE+
- · 细胞生物学实验-2023/06/01
- · 细胞自噬中ESCRT复合体对PI3K复合体I组装的数字式调控-2026/12/01
- · 利用脂化Atg8构建酵母人工细胞器-2025/03/01
- · 非经典自噬新途径分子机制的初步探索-2021/12/01
- · 非经典自噬新途径分子机制的初步探索-2021/12/01
- · 自噬东北亚学术研讨会-2014/12/01
- · 分子机器及人工细胞器精准组装-2025/10/01
- · 二酰甘油的稳态平衡及其对细胞内膜系统形态和功能的调控-2022/12/01
- · 高值化合物生物合成体系的智能组装及高效运行-2025/10/01
- · 针对嗅觉受体的酵母细胞质膜定位模块-2021/05/01